Takayuki Ikezoe Selected Research

Acute Eosinophilic Leukemia

9/2007

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.

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Takayuki Ikezoe Research Topics

Disease

42	Neoplasms (Cancer) 03/2024 - 01/2002
33	Leukemia 03/2020 - 05/2002
27	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 03/2024 - 10/2003
21	Disseminated Intravascular Coagulation 02/2024 - 11/2012
12	Prostatic Neoplasms (Prostate Cancer) 09/2007 - 09/2002
10	Hemorrhage 02/2024 - 06/2011
10	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 07/2023 - 05/2002
9	Thrombosis (Thrombus) 08/2023 - 08/2014
8	Hematologic Neoplasms (Hematological Malignancy) 01/2024 - 02/2004
8	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 09/2023 - 08/2014
8	Acute Promyelocytic Leukemia 12/2017 - 10/2003
7	Sepsis (Septicemia) 01/2023 - 12/2003
7	Multiple Myeloma 01/2021 - 02/2004
6	Lymphoma (Lymphomas) 03/2024 - 05/2002
6	Non-Hodgkin Lymphoma (Lymphosarcoma) 11/2023 - 04/2005
6	Myeloid Leukemia (Leukemia, Myelocytic) 09/2012 - 10/2003
4	Graft vs Host Disease (Graft-Versus-Host Disease) 03/2024 - 06/2008
4	Infections 01/2023 - 01/2018
4	Primary Myelofibrosis (Myelosclerosis) 01/2021 - 01/2017
4	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 03/2013 - 04/2005
3	Thrombocytopenia (Thrombopenia) 02/2024 - 01/2016
3	Hepatic Veno-Occlusive Disease (Disease, Hepatic Veno-Occlusive) 01/2021 - 01/2018
3	Fibrosis (Cirrhosis) 11/2017 - 02/2004
3	Fever (Fevers) 01/2015 - 10/2010
3	Blast Crisis (Blast Phase) 03/2014 - 10/2006
3	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 12/2013 - 09/2006
3	Breast Neoplasms (Breast Cancer) 08/2010 - 06/2003
3	Hypereosinophilic Syndrome (Loeffler Endocarditis) 08/2010 - 10/2006
3	Carcinogenesis 04/2008 - 09/2002
2	Niemann-Pick Diseases (Niemann Pick Disease) 12/2023 - 01/2022
2	COVID-19 12/2023 - 03/2021
2	Myocardial Ischemia (Ischemic Heart Diseases) 12/2022 - 08/2014
2	Hemolysis 04/2022 - 06/2018
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2022 - 11/2019
2	Inflammation (Inflammations) 01/2022 - 01/2017
2	Splenomegaly 01/2022 - 06/2017
2	Communicable Diseases (Infectious Diseases) 02/2021 - 01/2020
2	Thrombotic Microangiopathies 01/2021 - 01/2019

Drug/Important Bio-Agent (IBA)

19	Dacarbazine (DIC)FDA LinkGeneric 01/2024 - 11/2012
18	ThrombomodulinIBA 01/2024 - 11/2010
13	Proteins (Proteins, Gene)FDA Link 08/2022 - 02/2004
11	Phosphotransferases (Kinase)IBA 01/2022 - 01/2002
10	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2002
10	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2017 - 06/2003
7	Cytarabine (Cytosar-U)FDA LinkGeneric 03/2024 - 09/2009
7	NF-kappa B (NF-kB)IBA 06/2008 - 12/2003
7	AndrogensIBA 09/2007 - 11/2003
7	herbal preparation PC-SPESIBA 09/2007 - 09/2002
6	eculizumab FDA Link 01/2023 - 08/2014
6	CytokinesIBA 01/2022 - 12/2003
6	Aurora Kinase AIBA 01/2021 - 06/2007
5	AnticoagulantsIBA 01/2024 - 08/2014
5	Messenger RNA (mRNA)IBA 10/2020 - 06/2003
5	Everolimus FDA Link 03/2013 - 10/2006
5	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2010 - 06/2008
5	Androgen Receptors (Androgen Receptor)IBA 09/2007 - 11/2003
4	ravulizumabIBA 09/2023 - 10/2020
4	Monoclonal AntibodiesIBA 03/2023 - 09/2015
4	Histones (Histone)IBA 08/2022 - 01/2015
4	Tyrosine Kinase InhibitorsIBA 03/2021 - 02/2012
4	Imatinib Mesylate (Gleevec)FDA Link 12/2013 - 05/2008
4	Sunitinib (Sutent)FDA Link 02/2012 - 09/2006
4	TOR Serine-Threonine KinasesIBA 08/2010 - 10/2006
4	AZD 6244IBA 07/2010 - 06/2008
4	Human immunodeficiency virus 1 p16 proteaseIBA 08/2006 - 04/2004
3	AntithrombinsIBA 01/2023 - 01/2020
3	EnzymesIBA 01/2022 - 08/2006
3	MLN 8237IBA 01/2021 - 03/2014
3	Interleukin-10 (Interleukin 10)IBA 10/2020 - 03/2013
3	Lenalidomide (CC 5013)FDA Link 12/2018 - 06/2011
3	Calcineurin InhibitorsIBA 01/2018 - 09/2012
3	Epidermal Growth Factor (EGF)IBA 05/2017 - 05/2012
3	Transcription Factors (Transcription Factor)IBA 07/2011 - 05/2002
3	Aurora Kinase BIBA 01/2010 - 09/2007
3	Aurora KinasesIBA 04/2008 - 06/2007
3	Ritonavir (Norvir)FDA Link 08/2006 - 04/2004
3	Calcitriol (Calcijex)FDA LinkGeneric 08/2006 - 11/2002
3	Prostate-Specific Antigen (Semenogelase)IBA 03/2004 - 11/2003
2	Daunorubicin (Cerubidine)FDA LinkGeneric 03/2024 - 12/2022
2	olipudase alfaIBA 12/2023 - 01/2022
2	AntibodiesIBA 10/2023 - 05/2017
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 07/2023 - 10/2006
2	Immunoglobulin Light Chains (Immunoglobulin Light Chain)IBA 04/2023 - 12/2018
2	Bortezomib (Velcade)FDA Link 04/2023 - 03/2004
2	Azacitidine (5 Azacytidine)FDA Link 03/2023 - 05/2022
2	Rituximab (Mabthera)FDA Link 02/2023 - 11/2017
2	Complement Inactivating AgentsIBA 01/2023 - 10/2020
2	bcr-abl Fusion ProteinsIBA 01/2023 - 01/2017
2	Fibrinogen (Factor I)FDA Link 01/2023 - 02/2021
2	HMGB1 Protein (HMG1)IBA 06/2022 - 03/2020
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2021
2	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2022 - 04/2004
2	Dasatinib (BMS 354825)FDA Link 03/2021 - 03/2014

Therapy/Procedure

16	Therapeutics 03/2024 - 10/2003
11	Drug Therapy (Chemotherapy) 02/2024 - 12/2003
6	Hematopoietic Stem Cell Transplantation 11/2023 - 05/2017
3	Remission Induction 05/2021 - 07/2014
3	Stem Cell Transplantation 01/2021 - 06/2008
2	Enzyme Replacement Therapy 12/2023 - 01/2022
2	Transplantation 01/2021 - 01/2020